{"id":4717,"date":"2017-02-10T07:16:15","date_gmt":"2017-02-10T06:16:15","guid":{"rendered":"https:\/\/www.psychologyandi.com\/?p=4717"},"modified":"2017-02-10T07:16:15","modified_gmt":"2017-02-10T06:16:15","slug":"the-chemical-pathway-that-triggers-schizophrenia-symptoms","status":"publish","type":"post","link":"https:\/\/www.psychologyandi.com\/the-chemical-pathway-that-triggers-schizophrenia-symptoms\/","title":{"rendered":"The Chemical Pathway That Triggers Schizophrenia Symptoms"},"content":{"rendered":"<div style=\"display: block; float: left; margin: 8px 8px 8px 8px;\">\n<p><script src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\" async=\"\"><\/script><!-- Content --> <ins class=\"adsbygoogle\" style=\"display: inline-block; width: 300px; height: 250px;\" data-ad-client=\"ca-pub-8936035152699800\" data-ad-slot=\"4739053971\"><\/ins><script>\/\/ <![CDATA[\n(adsbygoogle = window.adsbygoogle || []).push({});\n\/\/ ]]><\/script><\/p>\n<\/div>\n<p style=\"text-align: justify;\">In a development towards finding a permanent and reliable<a href=\"https:\/\/www.psychologyandi.com\/can-smoking-be-linked-to-schizophrenia\/\"> cure to Schizophrenia<\/a>, a mental illness which has its causes hidden for ages: Researchers study the brain processes behind mental condition, via thorough investigation of kynurenic acid (KYNA) which plays a key role in the pathophysiology of schizophrenia.<\/p>\n<p style=\"text-align: justify;\">Earlier studies have shown people with Schizophrenia to posses higher levels of KYNA than healthy individuals.<\/p>\n<p style=\"text-align: justify;\">\n<div class='tm-tweet-clear'><\/div>\n<div class='tm-click-to-tweet'>\n<div class='tm-ctt-text'><a href='https:\/\/twitter.com\/share?text=+This+Triggers+Schizophrenia+Symptoms&#038;via=PsychDon&#038;related=PsychDon&#038;url=https:\/\/www.psychologyandi.com\/the-chemical-pathway-that-triggers-schizophrenia-symptoms\/' target='_blank'> This Triggers Schizophrenia Symptoms<\/a><\/div>\n<p><a href='https:\/\/twitter.com\/share?text=+This+Triggers+Schizophrenia+Symptoms&#038;via=PsychDon&#038;related=PsychDon&#038;url=https:\/\/www.psychologyandi.com\/the-chemical-pathway-that-triggers-schizophrenia-symptoms\/' target='_blank' class='tm-ctt-btn'>Click To Tweet<\/a><\/p>\n<div class='tm-ctt-tip'><\/div>\n<\/div>\n<p style=\"text-align: justify;\">From existing research, findings show that kynurenic acid (KYNA) has both positive and negative effects: it helps to metabolize tryptophan, the amino acid that helps the body to produce happiness. Consequentially, <strong>kynurenic acid (KYNA) decreases glutamate, an important neurotransmitter for healthy brain functioning<\/strong> &#8211; which, in turn, explains the<a href=\"http:\/\/www.medicalnewstoday.com\/articles\/315715.php\"> brain dysfunction in schizophrenia. <\/a><\/p>\n<p style=\"text-align: justify;\">Base on this hypothesis, a team of scientists from the University of Maryland School of Medicine in Baltimore led by Robert Schwarcz, Ph.D., a professor in the Department of Psychiatry, decide investigating the link between the kynurenic acid (KYNA) and schizophrenia-like behavior in mice. Researchers found that, kynurenine 3-monooxygenase enzyme (KMO)-deficient mice with high KYNA show <a href=\"https:\/\/www.psychologyandi.com\/6-arts-made-by-people-with-schizophrenia\/\">schizophrenia-like symptoms<\/a>.<\/p>\n<p style=\"text-align: justify;\">In the new <a href=\"http:\/\/www.biologicalpsychiatryjournal.com\/article\/S0006-3223(16)33112-2\/fulltext\">study <\/a>published in the journal <em>Biological Psychiatry, <\/em>researchers performed their experiment on mice that had their KMO deleted and characterized via the six schizophrenia-specific behavioral assays.<\/p>\n<h5 style=\"text-align: justify;\">Read also: <a href=\"https:\/\/www.psychologyandi.com\/the-diet-that-helps-fight-schizophrenia\/\">The Diet that Helps fight Schizophrenia<\/a><\/h5>\n<p style=\"text-align: justify;\">As expected, researchers found higher levels of KYNA in KMO-deficient mice. Genetically modified mice with KMO-deficient displayed contextual memory problems with increased <a href=\"http:\/\/www.medicalnewstoday.com\/info\/anxiety\/\">anxiety-like behavior<\/a>, which are all typical symptoms of Schizophrenia when compared with control mice.<\/p>\n<blockquote>\n<p style=\"text-align: justify;\">This study provides crucial new support for our longstanding hypothesis. It explains how the KYNA system may become dysfunctional in schizophrenia, concludes Prof. Robert Schwarcz.<\/p>\n<\/blockquote>\n<pre style=\"text-align: justify;\"><strong>Reference:\r\n<\/strong>\r\nProf. Robert Schwarcz et al. Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders - http:\/\/dx.doi.org\/10.1016\/j.biopsych.2016.12.011<\/pre>\n","protected":false},"excerpt":{"rendered":" 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